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Highly sensitive and selective colorimetric and off-on fluorescent chemosensor for Cu2+ in aqueous solution and living cells

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WOS被引频次:345
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成果类型:
期刊论文
作者:
Zhao, Yan;Zhang, Xiao-Bing;Han, Zhi-Xiang;Qiao, Li;Li, Chun-Yan;Jian, Li-Xin;Shen, Guo-Li;Yu, Ru-Qin
通讯作者:
Zhang, X.-B.(xbzhang@hnu.cn)
作者机构:
[Shen, Guo-Li; Zhang, Xiao-Bing; Yu, Ru-Qin; Han, Zhi-Xiang; Qiao, Li; Zhao, Yan; Jian, Li-Xin] State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China
[Li, Chun-Yan] Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, 411105, China
通讯机构:
[Zhang, Xiao-Bing] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China.
语种:
英文
关键词:
Aqueous solutions - Chemosensor - Detection limits - Direct measurement - Environmental Monitoring - Experimental conditions - Fluorescence intensities - Fluorescence quenching - Fluorescent detection - Fluorescent response - High concentration - Highly sensitive - Living cell - Paramagnetic nature - Ring opening - River water samples - Signal changes - Strong binding
期刊:
Analytical chemistry
ISSN:
0003-2700
年:
2009
卷:
81
期:
16
页码:
7022-7030
文献类别:
WOS:Review;EI:Journal article (JA)
所属学科:
ESI学科类别:化学;WOS学科类别:Chemistry, Analytical
入藏号:
WOS:000268907400058;EI:20093412269072;PMID:19634898
基金类别:
National Natural Science Foundation of China [20505008, 20605007, 20675028, 20775023]; National Key Basic Research Program of China [2007CB310500]; Ministry of Education of China [NCET-07-0272]; Hunan Natural Science Foundation [06JJ4010, 07JJ3025]
机构署名:
本校为其他机构
院系归属:
化学学院
环境与资源学院
摘要:
The design and synthesis of a novel rhodamine spirolactam derivative and its application in fluorescent detections of Cu<sup>2+</sup>in aqueous solution and living cells are reported. The signal change of the chemosensor is based on a specific metal ion induced reversible ring-opening mechanism of the rhodamine spirolactam. It exhibits a highly sensitive "turn-on" fluorescent response toward Cu<sup>2+</sup> in aqueous solution with an 80-fold fluorescence intensity enhancement under 10 equiv of Cu<sup>2+</sup>added. This indicates that the synthesized chemosensor effectively avoided the fluorescence quenching for the paramagnetic nature of Cu<sup>2+</sup> via its strong binding capability toward Cu<sup>2+</sup>. With the experimental conditions optimized, the probe exhibits a dynamic response range for Cu<sup>2+</sup> from 8.0 &times;10 <sup>-7</sup> to 1.0 &times;10<sup>-5</sup> M, with a detection limit of 3.0 &times;10<sup>-7</sup> M. The response of the chemosensor for Cu<sup>2+</sup> is instantaneous and reversible. Most importantly, both the color and fluorescence changes of the chemosensor are remarkably specific for Cu <sup>2+</sup> in the presence of other heavy and transition metal ions (even those that exist in high concentration), which meet the selective requirements for biomedical and environmental monitoring application. The proposed chemosensor has been used for direct measurement of Cu<sup>2+</sup> content in river water samples and imaging of Cu<sup>2+</sup> in living cells with satisfying results, which further demonstrates its value of practical applications in environmental and biological systems. &copy;2009 American Chemical Society.
参考文献:
ANTHONI U, 1995, STRUCT CHEM, V6, P161, DOI 10.1007/BF02286443
Barceloux DG, 1999, J TOXICOL-CLIN TOXIC, V37, P217
Barnham KJ, 2008, CURR OPIN CHEM BIOL, V12, P222, DOI 10.1016/j.cbpa.2008.02.019
Barranguet C, 2003, ENVIRON TOXICOL CHEM, V22, P1340, DOI 10.1897/1551-5028(2003)022<1340:CIMOTT>2.0.CO
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