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Atomic Structure of Human Adenovirus by Cryo-EM Reveals Interactions Among Protein Networks

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WOS被引频次:196
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成果类型:
期刊论文
作者:
Liu, Hongrong;Jin, Lei;Koh, Sok Boon S.;Atanasov, Ivo;Schein, Stan;Wu, Lily;Zhou, Z. Hong
通讯作者:
Zhou, ZH
作者机构:
[Atanasov, Ivo; Schein, Stan; Jin, Lei; Wu, Lily; Zhou, Z. Hong; Liu, Hongrong] Univ Calif Los Angeles, Calif Nanosyst Inst, Los Angeles, CA 90095 USA.
[Schein, Stan] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 USA.
[Schein, Stan] Univ Calif Los Angeles, Brain Res Inst, Los Angeles, CA 90095 USA.
[Jin, Lei; Zhou, Z. Hong; Liu, Hongrong] Univ Calif Los Angeles, Dept Microbiol Mol Genet & Immunol, Los Angeles, CA 90095 USA.
[Wu, Lily; Koh, Sok Boon S.] Univ Calif Los Angeles, Sch Med, Inst Mol Med IMED, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA.
通讯机构:
[Zhou, ZH] Univ Calif Los Angeles, Dept Microbiol Mol Genet & Immunol, Los Angeles, CA 90095 USA.
语种:
英文
期刊:
SCIENCE
ISSN:
0036-8075
年:
2010
卷:
329
期:
5995
页码:
1038-1043
文献类别:
WOS:Article
所属学科:
ESI学科类别:微生物学;WOS学科类别:Multidisciplinary Sciences
入藏号:
基金类别:
National Institutes of Health [GM071940, AI069015, CA101904, 1S10RR23057]; National Natural Scientific Foundation of China [10874144]; Congressionally Directed Medical Research Programs [W81XWH-06-1-055]
机构署名:
本校为其他机构
院系归属:
物理与光电工程学院
摘要:
Construction of a complex virus may involve a hierarchy of assembly elements. Here, we report the structure of the whole human adenovirus virion at 3.6 angstroms resolution by cryo-electron microscopy (cryo-EM), revealing in situ atomic models of three minor capsid proteins (IIIa, VIII, and IX), extensions of the (penton base and hexon) major capsid proteins, and interactions within three protein-protein networks. One network is mediated by protein IIIa at the vertices, within group-of-six (GOS) tiles-a penton base and its five surrounding hexons. Another is mediated by ropes (protein IX) that lash hexons together to form group-of-nine (GON) tiles and bind GONs to GONs. The third, mediated by IIIa and VIII, binds each GOS to five surrounding GONs. Optimization of adenovirus for cancer and gene therapy could target these networks.
参考文献:
Abrescia NGA, 2004, NATURE, V432, P68, DOI 10.1038/nature03056
BERK AJ, 2007, FIELDS VIROLOGY, V2, P2356
BOUDIN ML, 1980, VIROLOGY, V101, P144, DOI 10.1016/0042-6822(80)90491-2
BURNETT RM, 1985, J MOL BIOL, V185, P125, DOI 10.1016/0022-2836(85)90187-1
Cockburn JJB, 2004, NATURE, V432, P122, DOI 10.1038/nature03053

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