版权说明 帮助中心
首页 > 成果 > 详情

Preparation of dual-drug conjugated polymeric micelles with synergistic anti-cancer efficacy in vitro

SCI-E
认领
导出
Link by DOI
反馈
分享
QQ微信 微博
成果类型:
期刊论文
作者:
Wang, Wei;Zhao, Biyun;Meng, Xiangyang;She, Pan;Zhang, Pantian;Cao, Yi;Zhang, Xuefei
通讯作者:
Zhang, XF;Cao, Y
作者机构:
[Zhang, Xuefei; Wang, Wei; Zhao, Biyun; Zhang, Pantian; She, Pan; Meng, Xiangyang; Cao, Yi] Xiangtan Univ, Coll Chem, Minist Educ, Key Lab Environm Friendly Chem & Applicat, Xiangtan, Peoples R China.
[Zhang, Xuefei; Wang, Wei] Xiangtan Univ, Coll Chem, Key Lab Polymer Mat & Applicat Technol Hunan Prov, Xiangtan, Peoples R China.
[Zhao, Biyun; Zhang, Pantian; She, Pan; Meng, Xiangyang; Cao, Yi] Xiangtan Univ, Coll Chem, Lab Biochem, Xiangtan, Peoples R China.
通讯机构:
[Zhang, Xuefei; Cao, Yi] Xiangtan Univ, Coll Chem, Minist Educ, Key Lab Environm Friendly Chem & Applicat, Xiangtan, Peoples R China.
[Zhang, Xuefei] Xiangtan Univ, Coll Chem, Key Lab Polymer Mat & Applicat Technol Hunan Prov, Xiangtan, Peoples R China.
[Cao, Yi] Xiangtan Univ, Coll Chem, Lab Biochem, Xiangtan, Peoples R China.
语种:
英文
关键词:
Synergistic effect;Biodegradable;Nanotechnology;Polymer-drug conjugates
期刊:
Journal of Drug Delivery Science and Technology
ISSN:
1773-2247
年:
2018
卷:
43
页码:
388-396
文献类别:
WOS:Article
所属学科:
ESI学科类别:药理学&毒理学;WOS学科类别:Pharmacology & Pharmacy
入藏号:
基金类别:
National Natural Science Foundation of China [NSFC51273169, NSFC51473141]
机构署名:
本校为第一且通讯机构
院系归属:
化学学院
化工学院
环境与资源学院
摘要:
The traditional chemotherapy using single agent may suffer from serious drawbacks, particularly dose-limiting toxicity and relatively low antitumor efficacy, which can lead to failure of chemotherapy. Co-delivery of two or more therapeutic drugs in nanotechnology is a potential strategy to generate synergistic anticancer effects and reduce individual drug-related toxicity, but explosive release of each drug from multi-drug loaded nanoparticles has been a distinct obstacle. In this study, a novel amphiphilic and biodegradable triblock copolymer, named MPEG-b-norbornene functional PLA-b-P(alpha-BrCL), was constructed to covalently conjugate dual anticancer drugs, i.e., doxorubicin (DOX) and paclitaxel (PTX). The resultant P-PTX-DOX prodrugs were confirmed by H-1 NMR and HPLC. By adjusting the length of PLA and PCL, it was shown that this polymer could carry relatively sufficient amount of both drugs (12.1 wt% of PTX and 15.8 wt% of DOX, respectively). Moreover, the drug release profile of P-PTX-DOX in vitro was also analyzed, which showed the desired drug release in a sustained manner. Cytotoxicity study indicated synergistic effects of P-PTX-DOX self-assembled micelles in suppression of proliferation of A549 cancer cells. In summary, a novel polyester-based copolymer was developed to covalently conjugate dual-drug, which exhibited controlled drug release behavior and synergistic anti-cancer efficacy in vitro.
参考文献:
Aryal S, 2011, MOL PHARMACEUT, V8, P1401, DOI 10.1021/mp200243k
Baabur-Cohen H, 2017, J CONTROL RELEASE, V257, P118, DOI 10.1016/j.jconrel.2016.06.037
Bae Y, 2009, ADV DRUG DELIVER REV, V61, P768, DOI 10.1016/j.addr.2009.04.016
BARRY MA, 1990, BIOCHEM PHARMACOL, V40, P2353, DOI 10.1016/0006-2952(90)90733-2
Cao Y, 2017, J APPL TOXICOL, V37, P1359, DOI 10.1002/jat.3470

反馈

验证码:
看不清楚,换一个
确定
取消

成果认领

标题:
用户 作者 通讯作者
请选择
请选择
确定
取消

提示

该栏目需要登录且有访问权限才可以访问

如果您有访问权限,请直接 登录访问

如果您没有访问权限,请联系管理员申请开通

管理员联系邮箱:yun@hnwdkj.com