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Preparation of dual-drug conjugated polymeric micelles with synergistic anti-cancer efficacy in vitro

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WOS被引频次:1
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成果类型:
期刊论文
作者:
Wang, Wei;Zhao, Biyun;Meng, Xiangyang;She, Pan;Zhang, Pantian;Cao, Yi;Zhang, Xuefei
通讯作者:
Zhang, XF;Zhang, XF;Cao, Y
作者机构:
[Zhang, Xuefei; Wang, Wei; Zhao, Biyun; Zhang, Pantian; She, Pan; Meng, Xiangyang; Cao, Yi] Xiangtan Univ, Coll Chem, Minist Educ, Key Lab Environm Friendly Chem & Applicat, Xiangtan, Peoples R China.
[Zhang, Xuefei; Wang, Wei] Xiangtan Univ, Coll Chem, Key Lab Polymer Mat & Applicat Technol Hunan Prov, Xiangtan, Peoples R China.
[Zhao, Biyun; Zhang, Pantian; She, Pan; Meng, Xiangyang; Cao, Yi] Xiangtan Univ, Coll Chem, Lab Biochem, Xiangtan, Peoples R China.
通讯机构:
[Zhang, Xuefei; Cao, Yi] Xiangtan Univ, Coll Chem, Minist Educ, Key Lab Environm Friendly Chem & Applicat, Xiangtan, Peoples R China.
[Zhang, Xuefei] Xiangtan Univ, Coll Chem, Key Lab Polymer Mat & Applicat Technol Hunan Prov, Xiangtan, Peoples R China.
[Cao, Yi] Xiangtan Univ, Coll Chem, Lab Biochem, Xiangtan, Peoples R China.
语种:
英文
关键词:
Synergistic effect;Biodegradable;Nanotechnology;Polymer-drug conjugates
期刊:
Journal of Drug Delivery Science and Technology
ISSN:
1773-2247
年:
2018
卷:
43
页码:
388-396
文献类别:
WOS:Article
所属学科:
ESI学科类别:药理学&毒理学;WOS学科类别:Pharmacology & Pharmacy
入藏号:
基金类别:
National Natural Science Foundation of China [NSFC51273169, NSFC51473141]
机构署名:
本校为第一且通讯机构
院系归属:
化学学院
化工学院
环境与资源学院
摘要:
The traditional chemotherapy using single agent may suffer from serious drawbacks, particularly dose-limiting toxicity and relatively low antitumor efficacy, which can lead to failure of chemotherapy. Co-delivery of two or more therapeutic drugs in nanotechnology is a potential strategy to generate synergistic anticancer effects and reduce individual drug-related toxicity, but explosive release of each drug from multi-drug loaded nanoparticles has been a distinct obstacle. In this study, a novel amphiphilic and biodegradable triblock copolymer, named MPEG-b-norbornene functional PLA-b-P(α-BrCL), was constructed to covalently conjugate dual anticancer drugs, i.e., doxorubicin (DOX) and paclitaxel (PTX). The resultant P-PTX-DOX prodrugs were confirmed by 1H NMR and HPLC. By adjusting the length of PLA and PCL, it was shown that this polymer could carry relatively sufficient amount of both drugs (12.1 wt% of PTX and 15.8 wt% of DOX, respectively). Moreover, the drug release profile of P-PTX-DOX in vitro was also analyzed, which showed the desired drug release in a sustained manner. Cytotoxicity study indicated synergistic effects of P-PTX-DOX self-assembled micelles in suppression of proliferation of A549 cancer cells. In summary, a novel polyester-based copolymer was developed to covalently conjugate dual-drug, which exhibited controlled drug release behavior and synergistic anti-cancer efficacy in vitro.
参考文献:
Aryal S, 2011, MOL PHARMACEUT, V8, P1401, DOI 10.1021/mp200243k
Baabur-Cohen H, 2017, J CONTROL RELEASE, V257, P118, DOI 10.1016/j.jconrel.2016.06.037
Bae Y, 2009, ADV DRUG DELIVER REV, V61, P768, DOI 10.1016/j.addr.2009.04.016
BARRY MA, 1990, BIOCHEM PHARMACOL, V40, P2353, DOI 10.1016/0006-2952(90)90733-2
Cao Y, 2017, J APPL TOXICOL, V37, P1359, DOI 10.1002/jat.3470

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