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A ratiometric fluorescent probe for the detection of peroxynitrite with simple synthesis and large emission shift and its application in cells image

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成果类型:
期刊论文
作者:
Dong-YeZhou;JuanOu-Yang;YongfeiLi;Wen-LiJiang;YangTian;Zheng-MingYi;Chun-YanLi
通讯作者:
Li, Chun-Yan;Yi, Zheng-Ming
作者机构:
[Dong-YeZhou; Chun-YanLi; YangTian; Wen-LiJiang; JuanOu-Yang; YongfeiLi] Xiangtan Univ, Coll Chem, Key Lab Environm Friendly Chem & Applicat, Minist Educ,Key Lab Green Organ Synth & Applicat, Xiangtan 411105, Peoples R China.
[YongfeiLi; Zheng-MingYi] Xiangtan Univ, Coll Chem Engn, Xiangtan 411105, Peoples R China.
通讯机构:
[Li, Chun-Yan] Xiangtan Univ, Coll Chem, Key Lab Environm Friendly Chem & Applicat, Minist Educ,Key Lab Green Organ Synth & Applicat, Xiangtan 411105, Peoples R China.
[Yi, Zheng-Ming] Xiangtan Univ, Coll Chem Engn, Xiangtan 411105, Peoples R China.
语种:
英文
关键词:
Fluorescent probe;Peroxynitrite;Simple synthesis;Large emission shift;Cells image
期刊:
Dyes and Pigments
ISSN:
0143-7208
年:
2019
卷:
161
页码:
288-295
文献类别:
WOS:Article
所属学科:
WOS学科类别:Chemistry, Applied;Engineering, Chemical;Materials Science, Textiles
入藏号:
基金类别:
National Natural Science Foundation of China [21775133]; Hunan Provincial Natural Science Foundation [2018JJ2385]; Hunan 2011 Collaborative Innovation Center of Chemical Engineering & Technology with Environmental Benignity and Effective Resource Utilization
机构署名:
本校为第一且通讯机构
院系归属:
化学学院
化工学院
环境与资源学院
摘要:
Peroxynitrite (ONOO-) is an important kind of reactive oxygen species (ROS), played an essential role in physiology and pathology. To date, various fluorescent probes for ONOO- have been constructed successfully, but these probes exhibit turn-on fluorescence signal in single channel. While, ratiometric fluorescent probes, especially those probes with large emission shift, are suitable for bioimage in two channels. Herein, a hemicyanine-based fluorescent probe named Cy-NH2 was designed and synthesized for ratiometric detection of ONOO-. The characteristics of Cy-NH2 are as follows: (1) The probe possesses a simple structure, which can be obtained by easy synthetic steps; (2) The ratiometric fluorescent probe owns large emission shift (248 nm) due to the disruption of n-conjugation system caused by strong oxidizing ability of ONOO-; (3) The probe exhibits high sensitivity to ONOO- with 1728-fold enhancement of fluorescence intensity ratio and superior selectivity for ONOO- over various potentially interfering biological analytes; (4) The ratiometric fluorescent probe is applied for the image detection of exogenous and endogenous ONOO- in living cells successfully.
参考文献:
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BLOUGH NV, 1985, INORG CHEM, V24, P3502, DOI 10.1021/ic00216a003
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